Cushing's disease is a endocrine condition which can result in many different symptoms. The most common is sudden weight gain, especially around the trunk. Other symptoms include easy bruising, excessive urination, the formation of a "buffalo hump," unusual hair growth, high blood pressure and diabetes.
Cushing's Disease
Cushing's disease is caused by abnormally high levels of the hormone cortisol in the bloodstream.
Sources of Cortisol
The levels of cortisol can get abnormally high due to a tumor that either secretes cortisol or hormones that cause additional cortisol production. Cortisol levels can also be raised by taking too many corticosteroids.
Reasons to Take Corticosteroids
Corticosteroids are a useful method of treatment for many conditions, including asthma, organ transplants and rheumatoid arthritis.
Causes of Arthritis
Rheumatoid arthritis is an inflammatory disease in which the immune system attacks the joints and destroys the cartilage of the joints.
Mechanism of Corticosteroids
Corticosteroids work to suppress the immune system. Thus, taking corticosteroids can suppress the immune reaction that causes rheumatoid arthritis.
Connection Between Arthritis and Cushing's Disease
Using corticosteroids can result in Cushing's disease. Because corticosteroids are a common way of treating arthritis, people with arthritis can often develop Cushing's disease as a side effect of their treatment.
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